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Platelet dysfunction due to cigarette smoke An enhanced stimulatory and spontaneous aggregation of platelets isolated from smokers was observed (49)

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FIGURE 1 2.1 Mechanisms of mitochondrial dysfunction Mitochondrial dysfunction can arise through a wide array of genetic and environmental factors and has been implicated in a wide variety of pathological states

Additionally, outbred and inbred mouse strains can exhibit differential nicotine tolerance, which can further confound results and comparability among existing studies 34